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Researchers at Kumamoto University have identified a silencer element in the HTLV-1 genome that enables the virus to remain dormant by recruiting the host’s RUNX1 transcription factor. Removing this silencer reactivates the virus.

Subtle differences in molecular structure can have a major impact on the performance of mRNA-based drugs. The findings open the door to the development of safer and more effective vaccines and therapies.

Cancer cells coat themselves in a sugar to avoid the immune system, and now research has shown that dressing pancreatic beta cells in the same sugar enables the immune system to tolerate them.

A gene known as PSAT1, delivered through synthetic modified messenger RNA, can stimulate heart muscle repair and improve cardiac function following a heart attack.

Scientists at St. Jude Children’s Research Hospital verified the existence of “virtual memory T cells,” an immune cell type that explains how infants fight off early infections. The work stems from the X-SCID gene therapy trial.

The findings reveal that this common yet often underdiagnosed condition frequently occurs alongside a variety of other disorders, including some unexpected ones like cancer and asthma.

A new study details a way to selectively route mRNA to the pancreas by using the body’s own endogenous pathways – systems responsible for moving materials through the body.

Scientists reported administering an HIV gene therapy once to primates of different ages through simple injections into muscle tissue. The shot resulted in robust production of protective antibodies in nearly 90% of newborn macaques.

Researchers have developed a new system to assist authorities in distributing vaccines. The system uses data accessible to decision-makers. This can include the number of vaccines and the population count in each municipality.

Researchers have developed an optogenetics platform that enables precise spatiotemporal control over the storage and release of proteins and mRNAs in living cells and animals.