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Latest App Notes & Case Studies

Agilent report on TGF-β activity in angiogenesis research.
App Note / Case Study

High-Throughput, Quantitative Evaluation of TGF-β Signaling in Angiogenesis

This application note highlights how combining a phosphorylation and translocation assay with a confocal imaging reader can provide a robust and sophisticated method for analyzing the magnitude of SMAD activation. This in turn provides quantitative e
Agilent research paper on cAMP analysis with cADDis biosensor and live-cell imaging results
App Note / Case Study

Real-Time cAMP Analysis With cADDis Biosensor and Automated Live-Cell Imaging

This application note explores how, when coupled with live-cell imaging, these tools can offer improved sensitivity, faster turnaround and greater detail for Gs- and Gi- pathway monitoring.
Thermo Fisher Scientific technical note highlighting advances in mAb polishing using flow-through chromatography.
App Note / Case Study

Enhancing mAb Polishing With Advanced Flow-Through Technology

This app note details the application of advanced flow-through chromatography techniques, with case studies and practical guidance demonstrating how researchers can overcome complex polishing challenges to achieve high product quality and process eff
Gloved hand holding microcentrifuge tube in front of spectrophotometer data on lab computer screen
App Note / Case Study

Revolutionize Oligonucleotide Bioanalysis Using Automated SPE

This application note demonstrates how an integrated automated SPE workstation combined with next-generation triple quadrupole liquid chromatography–mass spectrometry (LC/MS) technology delivers superior sensitivity, reproducibility and efficiency fo
Scientist in lab coat and gloves performing maintenance on HPLC system in laboratory
App Note / Case Study

Choosing the Right SEC Column for Oligonucleotide Separation

This application note provides expert guidance on choosing the right SEC columns and optimizing method conditions to achieve reliable oligonucleotide separations.
3D rendering of DNA strands and molecular structures in turquoise tones representing genetic research
App Note / Case Study

Scale Up Oligonucleotide Purification With Cost-Effective Solutions

This application note presents a proven anion-exchange chromatography approach that delivers exceptional purification performance using standard aqueous buffers, enabling labs to achieve superior results while reducing costs and environmental impact.
A person wearing blue gloves places small vials into a blue sample holder in a laboratory, with scientific equipment visible in the background.
App Note / Case Study

Streamline Antisense Oligonucleotide QC With Robust LC/MS Purity Assessment

This application note demonstrates how advanced unit mass detection technology can deliver the sensitivity and selectivity required for comprehensive purity assessment, enabling routine testing labs to implement a more practical and robust analytical
Female scientist placing sample tubes into an automated lab analyzer in a modern laboratory.
App Note / Case Study

Streamline High-Throughput Oligonucleotide Analysis With Ion-Pairing-Free Methods

This application note demonstrates how an ammonium bicarbonate-based approach eliminates bottlenecks while maintaining excellent chromatographic performance and mass spectrometry sensitivity.
Abstract glowing orange DNA double helix with connected nodes on a dark network background
App Note / Case Study

Optimize Oligonucleotide Analysis With Advanced Chromatography Methods

This application note reveals how hydrophilic interaction chromatography (HILIC) provides a versatile, MS-compatible alternative that delivers superior separation performance without the limitations of conventional approaches.
Case study document showing lab technicians and equipment used for automating NGS-based HLA typing for stem cell transplantations
App Note / Case Study

Optimizing Donor Matching With Automated HLA Typing

This case study explores how a leading institution in histocompatibility implemented an automated NGS-based workflow for high-resolution HLA typing.
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