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Latest App Notes & Case Studies

Thermo Fisher Scientific technical note highlighting advances in mAb polishing using flow-through chromatography.
App Note / Case Study

Enhancing mAb Polishing With Advanced Flow-Through Technology

This app note details the application of advanced flow-through chromatography techniques, with case studies and practical guidance demonstrating how researchers can overcome complex polishing challenges to achieve high product quality and process eff
Scientist in lab coat and gloves performing maintenance on HPLC system in laboratory
App Note / Case Study

Choosing the Right SEC Column for Oligonucleotide Separation

This application note provides expert guidance on choosing the right SEC columns and optimizing method conditions to achieve reliable oligonucleotide separations.
3D rendering of DNA strands and molecular structures in turquoise tones representing genetic research
App Note / Case Study

Scale Up Oligonucleotide Purification With Cost-Effective Solutions

This application note presents a proven anion-exchange chromatography approach that delivers exceptional purification performance using standard aqueous buffers, enabling labs to achieve superior results while reducing costs and environmental impact.
A person wearing blue gloves places small vials into a blue sample holder in a laboratory, with scientific equipment visible in the background.
App Note / Case Study

Streamline Antisense Oligonucleotide QC With Robust LC/MS Purity Assessment

This application note demonstrates how advanced unit mass detection technology can deliver the sensitivity and selectivity required for comprehensive purity assessment, enabling routine testing labs to implement a more practical and robust analytical
Female scientist placing sample tubes into an automated lab analyzer in a modern laboratory.
App Note / Case Study

Streamline High-Throughput Oligonucleotide Analysis With Ion-Pairing-Free Methods

This application note demonstrates how an ammonium bicarbonate-based approach eliminates bottlenecks while maintaining excellent chromatographic performance and mass spectrometry sensitivity.
Abstract glowing orange DNA double helix with connected nodes on a dark network background
App Note / Case Study

Optimize Oligonucleotide Analysis With Advanced Chromatography Methods

This application note reveals how hydrophilic interaction chromatography (HILIC) provides a versatile, MS-compatible alternative that delivers superior separation performance without the limitations of conventional approaches.
Front cover of a Cytiva and Nuclera application note on accelerated kinase drug discovery workflow.
App Note / Case Study

Speed Up Kinase Drug Target Characterization

This application note presents a next-generation approach to drug discovery - combining AI-guided structural design with rapid, automated digital microfluidics-based screening workflows that optimize protein expression. Researchers can obtain purifi
Doctor holding a glowing capsule symbolizing AI-driven drug discovery and molecular innovation
App Note / Case Study

AI-Driven Therapeutic Antibody Design

This application note explores how researchers successfully combined AI with advanced multiplexed gene synthesis to design and validate novel single-domain antibodies with atomic-level precision.
The bio-techne Ella on a blue background with different cells surrounding it.
App Note / Case Study

Accelerate HCP Detection With a High Precision Immunoassay

This app note highlights how a microfluidic immunoassay simplifies HCP detection using integrated reagents and automation.
The front of Thermo Fisher Scientific's app note for PFAS screening pharmaceutical packaging
App Note / Case Study

Extractables and Leachables Analysis: PFAS Screening in the Pharmaceutical Industry

Proactive detection and risk mitigation are essential to ensure product safety and compliance with future regulations. This app note showcases a comprehensive screening solution that can ensure targeted and accurate PFAS screening.

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