Latest App Notes & Case Studies

App Note / Case Study
High-Throughput, Quantitative Evaluation of TGF-β Signaling in Angiogenesis
This application note highlights how combining a phosphorylation and translocation assay with a confocal imaging reader can provide a robust and sophisticated method for analyzing the magnitude of SMAD activation. This in turn provides quantitative e

App Note / Case Study
Real-Time cAMP Analysis With cADDis Biosensor and Automated Live-Cell Imaging
This application note explores how, when coupled with live-cell imaging, these tools can offer improved sensitivity, faster turnaround and greater detail for Gs- and Gi- pathway monitoring.

App Note / Case Study
Enhancing mAb Polishing With Advanced Flow-Through Technology
This app note details the application of advanced flow-through chromatography techniques, with case studies and practical guidance demonstrating how researchers can overcome complex polishing challenges to achieve high product quality and process eff

App Note / Case Study
Revolutionize Oligonucleotide Bioanalysis Using Automated SPE
This application note demonstrates how an integrated automated SPE workstation combined with next-generation triple quadrupole liquid chromatography–mass spectrometry (LC/MS) technology delivers superior sensitivity, reproducibility and efficiency fo

App Note / Case Study
Choosing the Right SEC Column for Oligonucleotide Separation
This application note provides expert guidance on choosing the right SEC columns and optimizing method conditions to achieve reliable oligonucleotide separations.

App Note / Case Study
Scale Up Oligonucleotide Purification With Cost-Effective Solutions
This application note presents a proven anion-exchange chromatography approach that delivers exceptional purification performance using standard aqueous buffers, enabling labs to achieve superior results while reducing costs and environmental impact.

App Note / Case Study
Streamline Antisense Oligonucleotide QC With Robust LC/MS Purity Assessment
This application note demonstrates how advanced unit mass detection technology can deliver the sensitivity and selectivity required for comprehensive purity assessment, enabling routine testing labs to implement a more practical and robust analytical

App Note / Case Study
Streamline High-Throughput Oligonucleotide Analysis With Ion-Pairing-Free Methods
This application note demonstrates how an ammonium bicarbonate-based approach eliminates bottlenecks while maintaining excellent chromatographic performance and mass spectrometry sensitivity.

App Note / Case Study
Optimize Oligonucleotide Analysis With Advanced Chromatography Methods
This application note reveals how hydrophilic interaction chromatography (HILIC) provides a versatile, MS-compatible alternative that delivers superior separation performance without the limitations of conventional approaches.

App Note / Case Study
Why Automation Is Integral to the EU-OPENSCREEN Compound Collection
This case study highlights how EU-OPENSCREEN implemented a fully automated workflow for compound dissolution, aliquoting, storage and plate reformatting, meeting the scale and speed of modern screening demands.
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